New research reveals that people who stop using popular slimming jabs like semaglutide or tirzepatide may regain shed pounds much more quickly than those who stop conventional diet and exercise plans.
Published data in a major medical journal demonstrates that while overweight individuals often shed substantial amounts of their total mass while undergoing treatment, the weight comes back at an estimated rate of nearly a kilo each month once they quit.
"People using these treatments must be informed of the risk of fast weight regain when the medication ends," cautioned expert Dr. Susan Jebb.
Such speed of regain means a return to original weight within about 18 months.
Weighing Therapies
The study, which reviewed dozens of trials involving thousands of patients, contrasted the outcomes of the injectable medications with older methods.
Scientists point out that people who shed pounds through dieting typically experience a less rapid creep back—around 100 grams monthly—post-intervention.
The Reason for the Rapid Rebound
Doctors propose the way of the jabs accounts for the amplified rebound.
These medications copy a natural hormone called glucagon-like peptide-1, which helps regulate hunger.
"Artificially providing the hormone concentrations several times higher than the body's typical production may cause the system to produce less of its own natural GLP-1, and may also reduce sensitivity to its actions," noted Dr. Adam Collins, a nutrition specialist.
"Withdrawal of this medication results in appetite is no longer kept in check, making excessive eating far more likely."
A Chronic Issue?
The NHS recommend the jabs for people with obesity-related health risks, alongside recommended diet and exercise modifications.
A number of clinicians argue that, given the significant potential of weight regain, the therapy might need to be ongoing.
This perspective is reinforced by drug manufacturers, who say that the results "emphasize the chronic nature of excess weight," similar to managing diseases like high blood pressure.
User Testimonies
Individuals who have stopped the medication report a powerful resurgence of hunger.
"I experienced a trigger flipping and you become extremely hungry," said an individual.
This difficulty is compounded if users have not established permanent dietary or behavioural changes during treatment.
Significant Use
Recent estimates suggest that millions of adults in the UK have tried these injections in the last 12 months, with desire being substantial.
- Use is higher among women than men.
- The 40s and 50s age group shows the highest level of interest.
- Many obtain the medications through private prescriptions rather than public health services.
Finally, experts caution that while these medications are effective agents for weight loss, they are not a standalone fix and lasting health benefits likely depends on combined lifestyle management.
